[Week 3's Topic] - Acetyl l-Carnitine (ALCAR)

**Proverbs** · 05-24-2005, 12:03 AM

This weeks discussion ... ALCAR

Acetyl l-Carnitine (ALCAR) helps improve performance, burn fat and enhance recovery. ALCAR can also help improve memory, learning capacity, cardiovascular function, hearin and visual function, and reduce stress and depression.

Let's hear what everyone has to say ...

Does it work?
What are your experiences with ALCAR?
Which are the best/worst products containing ALCAR?
What are the pros and/or cons of ALCAR supplementation?
Other thoughts, opinions, etc.

Shilling · 05-24-2005, 01:35 AM

I think these topics should be better known. I've never even heard of this, let alone have any sort of simple knowledge on it. Can't we just do something like...Manta Ray squat pads? Heh.

**Proverbs** · 05-24-2005, 01:43 AM

If you're not familiar with the topic don't post about it .. a variety of other topics will follow in the weeks to come.

Vegeto · 05-24-2005, 02:47 AM

Quote:

Originally Posted by PROVERBS 4:13

If you're not familiar with the topic don't post about it .. a variety of other topics will follow in the weeks to come.

Try and stop me PROVERBS!

...Na, I'll leave this to those who can afford sups.

**DarkFalcon** · 05-24-2005, 03:44 AM

Quote:

Originally Posted by PROVERBS 4:13

This weeks discussion ... ALCAR

Acetyl l-Carnitine (ALCAR) helps improve performance, burn fat and enhance recovery. ALCAR can also help improve memory, learning capacity, cardiovascular function, hearin and visual function, and reduce stress and depression.

Let's hear what everyone has to say ...

Does it work?
What are your experiences with ALCAR?
Which are the best/worst products containing ALCAR?
What are the pros and/or cons of ALCAR supplementation?
Other thoughts, opinions, etc.

To be honest I've never tried it. Any experience with it yourself Provs?

The Doc · 05-24-2005, 08:23 AM

I've only ever tried it in my homemade Psychotropin blend, never on it's own. Maybe next time I order the bulk powders I'll try it alone and create a log, sorry I couldn't be more help

.

**Proverbs** · 05-25-2005, 09:57 PM

Quote:

Originally Posted by DarkFalcon

To be honest I've never tried it. Any experience with it yourself Provs?

I've only used it in NeuroStim, I was hoping more people would be able to comment on it

Big H · 05-25-2005, 10:03 PM

I've used it a lot, being that it is in NO products. I got decent results, nothing to jump about, but it did help the overall NO product.

**DarkFalcon** · 05-25-2005, 10:05 PM

Quote:

Originally Posted by PROVERBS 4:13

I've only used it in NeuroStim, I was hoping more people would be able to comment on it

Well how about this, you paypal me the money and I'll be your lab rat. I'll even post a log.

**Proverbs** · 05-25-2005, 10:06 PM

Quote:

Originally Posted by DarkFalcon

Well how about this, you paypal me the money and I'll be your lab rat. I'll even post a log.

LOL

drewkowsky · 05-26-2005, 01:01 AM

hi guys first post here

on ALCAR:
I've used it
I liked it
great focus and mental energy; no noticeable fat loss benefits

**DarkFalcon** · 05-26-2005, 01:10 AM

Quote:

Originally Posted by drewkowsky

hi guys first post here

on ALCAR:
I've used it
I liked it
great focus and mental energy; no noticeable fat loss benefits

Hey drew good to see you over here.

drewkowsky · 05-26-2005, 01:13 AM

Quote:

Originally Posted by DarkFalcon

Hey drew good to see you over here.

thanks Dark
seems like a cool board you guys got going on over here

**DarkFalcon** · 05-26-2005, 01:17 AM

Quote:

Originally Posted by drewkowsky

thanks Dark
seems like a cool board you guys got going on over here

Ya it's still in it's infancy but A LOT of the best BB.com members are here now or on their way.

Diab0lic · 05-26-2005, 11:03 AM

Ann N Y Acad Sci. 2004 Nov;1033:30-41.

Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism.

Rebouche CJ.

Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA. charles-rebouche@uiowa.edu

In mammals, the carnitine pool consists of nonesterified L-carnitine and many acylcarnitine esters. Of these esters, acetyl-L-carnitine is quantitatively and functionally the most significant. Carnitine homeostasis is maintained by absorption from diet, a modest rate of synthesis, and efficient renal reabsorption. Dietary L-carnitine is absorbed by active and passive transfer across enterocyte membranes. Bioavailability of dietary L-carnitine is 54-87% and is dependent on the amount of L-carnitine in the meal. Absorption of L-carnitine dietary supplements (0.5-6 g) is primarily passive; bioavailability is 14-18% of dose. Unabsorbed L-carnitine is mostly degraded by microorganisms in the large intestine. Circulating L-carnitine is distributed to two kinetically defined compartments: one large and slow-turnover (presumably muscle), and another relatively small and rapid-turnover (presumably liver, kidney, and other tissues). At normal dietary L-carnitine intake, whole-body turnover time in humans is 38-119 h. In vitro experiments suggest that acetyl-L-carnitine is partially hydrolyzed in enterocytes during absorption. In vivo, circulating acetyl-L-carnitine concentration was increased 43% after oral acetyl-L-carnitine supplements of 2 g/day, indicating that acetyl-L-carnitine is absorbed at least partially without hydrolysis. After single-dose intravenous administration (0.5 g), acetyl-L-carnitine is rapidly, but not completely hydrolyzed, and acetyl-L-carnitine and L-carnitine concentrations return to baseline within 12 h. At normal circulating l-carnitine concentrations, renal l-carnitine reabsorption is highly efficient (90-99% of filtered load; clearance, 1-3 mL/min), but displays saturation kinetics. Thus, as circulating L-carnitine concentration increases (as after high-dose intravenous or oral administration of L-carnitine), efficiency of reabsorption decreases and clearance increases, resulting in rapid decline of circulating L-carnitine concentration to baseline. Elimination kinetics for acetyl-L-carnitine are similar to those for L-carnitine. There is evidence for renal tubular secretion of both L-carnitine and acetyl-L-carnitine. Future research should address the correlation of supplement dosage, changes and maintenance of tissue L-carnitine and acetyl-L-carnitine concentrations, and metabolic and functional changes and outcomes.

ALCAR has also shown to be significantly better than placebo in the treatment of neuropathic pain from diabetes and in cognitive and dementia studies also. It is neuroprotective and is involved in membrane phospholipid metabolism.

http://www.bodybuilding.com/store/alcprice.html

It seems to be about $US4-5 per 10g which would last you a few days at avg 3g/day (dose=0.5-6.0 g/day). Id give it a go, but Id honestly rather spend that money on good meat, fish and vegetables. It seems like its not a bad supp, its just whether you think its cost effective I guess (which depends on your supp budget amongst other things)

**builtbeast** · 05-31-2005, 09:16 AM

Now that we're on the next week's topic thought I'd post some other's opinions of Acetyl L-Carnitine.

good post:
http://www.anabolicminds.com/forum/s...34&postcount=3

thread:
http://www.anabolicminds.com/forum/s...ead.php?t=5553

Apootheosis · 06-02-2005, 11:19 PM

I got 500 grams of this shit. Studies have made it out to be super-pwnage. my experience is yes, it r teh 1337sauce. over 2 table spoons and your vision starts to get clearer and u get a little weird feeling in your sinuses.

taste = imagine a 1M concentrated solution of vinegar.....disgusting. absolutely horrible taste

Thing · 06-04-2005, 05:07 PM

It sounds like the way CEE tastes, like friggin' battery acid!! That's some nasty tasting stuff!!
ROB

05-24-2005, 12:03 AM	#1
Proverbs Mr. Warm & Easy Join Date: May 2005 Posts: 5,296 Recipes: 0 Rep Power: 226	[Week 3's Topic] - Acetyl l-Carnitine (ALCAR) This weeks discussion ... ALCAR Acetyl l-Carnitine (ALCAR) helps improve performance, burn fat and enhance recovery. ALCAR can also help improve memory, learning capacity, cardiovascular function, hearin and visual function, and reduce stress and depression. Let's hear what everyone has to say ... Does it work? What are your experiences with ALCAR? Which are the best/worst products containing ALCAR? What are the pros and/or cons of ALCAR supplementation? Other thoughts, opinions, etc. __________________ Last edited by Proverbs : 05-28-2005 at 08:24 PM.

05-24-2005, 01:43 AM	#3
Proverbs Mr. Warm & Easy Join Date: May 2005 Posts: 5,296 Recipes: 0 Rep Power: 226	If you're not familiar with the topic don't post about it .. a variety of other topics will follow in the weeks to come. __________________

05-24-2005, 08:23 AM	#6
The Doc Pro Stature Join Date: May 2005 Location: Lockport,NY Posts: 232 Recipes: 0 Rep Power: 6	I've only ever tried it in my homemade Psychotropin blend, never on it's own. Maybe next time I order the bulk powders I'll try it alone and create a log, sorry I couldn't be more help . __________________ I do not have an M.D. or a Ph.D., Doc is a nickname, please don't ask me about your personal itching or psychological problems. A smart man learns from his own mistakes, a wise man learns from the mistakes of others. IAmShaman Shop

05-25-2005, 10:03 PM	#8
Big H Picked Up at the Curb Join Date: May 2005 Posts: 120 Recipes: 0 Rep Power: 5	I've used it a lot, being that it is in NO products. I got decent results, nothing to jump about, but it did help the overall NO product. __________________ WWW.NUTRIBEAST.COM

05-26-2005, 11:03 AM	#15
Diab0lic Pro Stature Join Date: May 2005 Location: NZ Posts: 125 Recipes: 0 Rep Power: 7	Ann N Y Acad Sci. 2004 Nov;1033:30-41. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Rebouche CJ. Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA. charles-rebouche@uiowa.edu In mammals, the carnitine pool consists of nonesterified L-carnitine and many acylcarnitine esters. Of these esters, acetyl-L-carnitine is quantitatively and functionally the most significant. Carnitine homeostasis is maintained by absorption from diet, a modest rate of synthesis, and efficient renal reabsorption. Dietary L-carnitine is absorbed by active and passive transfer across enterocyte membranes. Bioavailability of dietary L-carnitine is 54-87% and is dependent on the amount of L-carnitine in the meal. Absorption of L-carnitine dietary supplements (0.5-6 g) is primarily passive; bioavailability is 14-18% of dose. Unabsorbed L-carnitine is mostly degraded by microorganisms in the large intestine. Circulating L-carnitine is distributed to two kinetically defined compartments: one large and slow-turnover (presumably muscle), and another relatively small and rapid-turnover (presumably liver, kidney, and other tissues). At normal dietary L-carnitine intake, whole-body turnover time in humans is 38-119 h. In vitro experiments suggest that acetyl-L-carnitine is partially hydrolyzed in enterocytes during absorption. In vivo, circulating acetyl-L-carnitine concentration was increased 43% after oral acetyl-L-carnitine supplements of 2 g/day, indicating that acetyl-L-carnitine is absorbed at least partially without hydrolysis. After single-dose intravenous administration (0.5 g), acetyl-L-carnitine is rapidly, but not completely hydrolyzed, and acetyl-L-carnitine and L-carnitine concentrations return to baseline within 12 h. At normal circulating l-carnitine concentrations, renal l-carnitine reabsorption is highly efficient (90-99% of filtered load; clearance, 1-3 mL/min), but displays saturation kinetics. Thus, as circulating L-carnitine concentration increases (as after high-dose intravenous or oral administration of L-carnitine), efficiency of reabsorption decreases and clearance increases, resulting in rapid decline of circulating L-carnitine concentration to baseline. Elimination kinetics for acetyl-L-carnitine are similar to those for L-carnitine. There is evidence for renal tubular secretion of both L-carnitine and acetyl-L-carnitine. Future research should address the correlation of supplement dosage, changes and maintenance of tissue L-carnitine and acetyl-L-carnitine concentrations, and metabolic and functional changes and outcomes. ALCAR has also shown to be significantly better than placebo in the treatment of neuropathic pain from diabetes and in cognitive and dementia studies also. It is neuroprotective and is involved in membrane phospholipid metabolism. http://www.bodybuilding.com/store/alcprice.html It seems to be about $US4-5 per 10g which would last you a few days at avg 3g/day (dose=0.5-6.0 g/day). Id give it a go, but Id honestly rather spend that money on good meat, fish and vegetables. It seems like its not a bad supp, its just whether you think its cost effective I guess (which depends on your supp budget amongst other things) __________________

05-24-2005, 01:35 AM	#2
Shilling Amateur Join Date: Apr 2005 Posts: 82 Recipes: 0 Rep Power: 4	I think these topics should be better known. I've never even heard of this, let alone have any sort of simple knowledge on it. Can't we just do something like...Manta Ray squat pads? Heh.

05-26-2005, 01:01 AM	#11
drewkowsky New Member Join Date: May 2005 Posts: 21 Recipes: 0 Rep Power: 0	hi guys first post here on ALCAR: I've used it I liked it great focus and mental energy; no noticeable fat loss benefits

05-31-2005, 09:16 AM	#16
builtbeast Großer Moderator Join Date: May 2005 Location: In a very red state Posts: 1,828 Recipes: 0 Rep Power: 98	Now that we're on the next week's topic thought I'd post some other's opinions of Acetyl L-Carnitine. good post: http://www.anabolicminds.com/forum/s...34&postcount=3 thread: http://www.anabolicminds.com/forum/s...ead.php?t=5553

06-02-2005, 11:19 PM	#17
Apootheosis Pro Stature Join Date: May 2005 Posts: 626 Recipes: 0 Rep Power: 10	I got 500 grams of this shit. Studies have made it out to be super-pwnage. my experience is yes, it r teh 1337sauce. over 2 table spoons and your vision starts to get clearer and u get a little weird feeling in your sinuses. taste = imagine a 1M concentrated solution of vinegar.....disgusting. absolutely horrible taste

06-04-2005, 05:07 PM	#18
Thing Pro Stature Join Date: Jun 2005 Posts: 132 Recipes: 0 Rep Power: 5	CEE It sounds like the way CEE tastes, like friggin' battery acid!! That's some nasty tasting stuff!! ROB __________________ MOTIVATED, DEDICATED, LETHAL.... US ARMY RANGERS LEAD THE WAY