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Old 05-20-2006, 03:06 AM   #1
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Default Press Release: X factor induces hypertrophy in-vitro!

Quote:
Originally Posted by Molecular Nutrition
X-Factorä Induces Hypertrophy in-vitro.

Study at Benedictine University suggests X-factor™ to be a primary hypertrophic trigger in accruing lean muscle mass.

May 17, 2006: Jupiter, FL. Dr. Craig Broeder and a team of scientists at Benedictine University have released a preliminary report concerning their recent work with arachidonic acid, the patented main ingredient in Molecular Nutrition's X-Factor™. Entitled, "THE EFFECTS OF ARACHIDONIC ACID SUPPLEMENTATION ON MYOTUBE DEVELOPMENT", the report pertains to a series of in-vitro investigations whose purpose was to measure arachidonic acid's effect on protein synthesis, myocyte fusion, lectin expression, prostaglandin synthesis, and overall hypertrophy in myotubes. The findings demonstrated that arachidonic acid may enhance the process of myotube differentiation, or in layman's terms, greatly accelerate muscle growth.
According to the report, clear phenotypic changes were observed in cells exposed to arachidonic acid. These verified changes include [b]increased lateral diameter in myotubes, enhanced levels of myosin deposition, and greater concentration of nuclei.[b/] Such results further reinforce our understanding of arachidonic acid as an ergogen by showing that it does indeed augment muscle's hypertrophic response through enhanced cellular myotube growth, acting as a [b]primary hypertrophic catalyst[b/] in a complex hormonal cascade that regulates the growth of skeletal muscle tissue.
In physically active people, X-Factor™ builds stores of arachidonic acid within the muscles, where it will intensify the response of the prostaglandin system to training stimulus. This leads to increases in protein synthesis in stressed muscle. With Molecular Nutrition being the only company legally allowed to sell arachidonic acid as an performance aid, X-Factor™ is truly one-of-a-kind within the realm of ergogenic supplements. This recently released preliminary study--adding the scores of scientific evidence elucidating the relevance of arachidonic acid supplementation in muscle growth--marks only the beginning of Molecular Nutrition's goal to fully substantiate arachidonic acid and X-Factor™ within the scientific and athletic communities.
This is definitely a good thing!

What is my take on this? And how does this invitro study apply to us so far?

Well it clearly demonstrates that AA added exogenously to a cell (under favorable ATP conditions I'm assuming) is responsible for adaptative changes that include increased fiber diameter and protein synthesis. This is pretty huge and will eventually pave the way to a new understanding of the phospholipid bilayer in bodybuilding.

Now In a training human that was able to accumulate Arachidonic acid (and stabilize it under resting conditions) it would be this Arachidonic acid released upon the muscle contraction that would signal to cell to become stronger.

More studies will follow and over time. I'm hoping the ideal use of this key nutrient will be even more optimized in the future as learn more.
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Old 05-20-2006, 04:27 AM   #2
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Pretty strong endorsement for AA. Maybe I will try it after all.
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Old 05-21-2006, 10:40 AM   #3
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That word "may", as in "might", is a pretty big word as far as I'm concerned. And I have trialed X-Factor already.
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Old 05-22-2006, 02:53 PM   #4
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Originally Posted by powerman2000
That word "may", as in "might", is a pretty big word as far as I'm concerned. And I have trialed X-Factor already.
I think the reason why they are occassionally non-responders is because the process of turning AA into a phospholipid is ATP/magnesium dependent. In this way arachidonic acid can almost limit its uptake in a negative feedback sort of fashion. That is why I have never been against using certain beneficial ATP producing supplements with x factor (even if they are suspected of having some slight anti-inflammatory effect)

I think eventually the use of this nutrient will be far more perfected in the future so the maximum effects can be realized for a greater amount of people. Actually the fact that fish oil can improve the efficiency of the electron transport chain makes me think its not neccessarily antagonist towards arachidonic acid provided the doses are matched in some way.
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