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Old 05-12-2005, 11:26 PM   #1
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Post Flax Seed & Prostrate Cancer


Recently there has been some discussion about this issue, here are some studies to review:



Nutr J. 2004 Oct 20;3(1):19.

Nutrition and cancer: A review of the evidence for an anti-cancer diet.

Donaldson MS.

Director of Research, Hallelujah Acres Foundation, 13553 Vantage Hwy, Ellensburg, WA 98926, USA.

It has been estimated that 30-40 percent of all cancers can be prevented by lifestyle and dietary measures alone. Obesity, nutrient sparse foods such as concentrated sugars and refined flour products that contribute to impaired glucose metabolism (which leads to diabetes), low fiber intake, consumption of red meat, and imbalance of omega 3 and omega 6 fats all contribute to excess cancer risk. Intake of flax seed, especially its lignan fraction, and abundant portions of fruits and vegetables will lower cancer risk. Allium and cruciferous vegetables are especially beneficial, with broccoli sprouts being the densest source of sulforophane. Protective elements in a cancer prevention diet include selenium, folic acid, vitamin B-12, vitamin D, chlorophyll, and antioxidants such as the carotenoids (alpha-carotene, beta-carotene, lycopene, lutein, cryptoxanthin). Ascorbic acid has limited benefits orally, but could be very beneficial intravenously. Supplementary use of oral digestive enzymes and probiotics also has merit as anticancer dietary measures. When a diet is compiled according to the guidelines here it is likely that there would be at least a 60-70 percent decrease in breast, colorectal, and prostate cancers, and even a 40-50 percent decrease in lung cancer, along with similar reductions in cancers at other sites. Such a diet would be conducive to preventing cancer and would favor recovery from cancer as well.

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15496224


________________________________________


Urology. 2004 May;63(5):900-4.

Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen.

Demark-Wahnefried W, Robertson CN, Walther PJ, Polascik TJ, Paulson DF, Vollmer RT.

Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

OBJECTIVES: Dietary factors may influence the prostate and have an impact on prostatic growth and disease. A small number of studies have suggested that flaxseed-supplemented, fat-restricted diets may thwart prostate cancer growth in both animals and humans. Unknown, however, is the potential effect of such a diet on benign prostatic epithelium. METHODS: We undertook a pilot study to explore whether a flaxseed-supplemented, fat-restricted diet affects the proliferation rates in benign epithelium. We also explored the effects on circulating levels of prostate-specific antigen (PSA), total testosterone, and cholesterol. Fifteen men who were scheduled to undergo repeat prostate biopsy were instructed to follow a low-fat (less than 20% kcal), flaxseed-supplemented (30 g/day) diet and were provided with a supply of flaxseed to last throughout the 6-month intervention period. The PSA, total testosterone, and cholesterol levels were determined at baseline and at 6 months of follow-up. Reports from the original and repeat biopsies were compared, and proliferation (MIB-1) rates were quantified in the benign prostatic epithelium. RESULTS: Statistically significant decreases in PSA (8.47 +/- 3.82 to 5.72 +/- 3.16 ng/mL; P = 0.0002) and cholesterol (241.1 +/- 30.8 to 213.3 +/- 51.2 mg/dL; P = 0.012) were observed. No statistically significant change was seen in total testosterone (434.5 +/- 143.6 to 428.3 +/- 92.5 ng/dL). Although 6-month repeat biopsies were not performed in 2 cases because of PSA normalization, of the 13 men who underwent repeat biopsy, the proliferation rates in the benign epithelium decreased significantly from 0.022 +/- 0.027 at baseline to 0.007 +/- 0.014 at 6 months of follow-up (P = 0.0168). CONCLUSIONS: These pilot data suggest that a flaxseed-supplemented, fat-restricted diet may affect the biology of the prostate and associated biomarkers. A randomized controlled trial is needed to determine whether flaxseed supplementation, a low-fat diet, or a combination of the two regimens may be of use in controlling overall prostatic growth.

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15134976


________________________________________



Urology. 2002 Nov;60(5):919-24.

Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice.

Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.

Division of Urologic Surgery, Department of Surgery, and Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA.

OBJECTIVES: To investigate the effects of flaxseed supplementation on prostatic neoplasia in the transgenic adenocarcinoma mouse prostate (TRAMP) model. METHODS: A total of 135 male TRAMP mice 5 to 6 weeks old were randomized to a control group (AIN-76A diet) or an experimental group (AIN-76A diet plus 5% flaxseed by weight). One half of the mice in each group were treated for 20 weeks and the remainder for 30 weeks. At autopsy, urogenital tissues (four prostatic lobes, seminal vesicles, and emptied bladder), lungs, lymph nodes, and grossly abnormal tissues were collected for histologic evaluation. RESULTS: Of the control mice, 100% developed prostate cancer versus 97% of the mice in the flaxseed group. The tumor/urogenital weight was 3.6 +/- 0.4 g in the controls versus 1.9 +/- 0.2 g in the flaxseed-treated mice (P = 0.0005). At 20 weeks, no significant difference in tumor grade was seen between the two groups; however, at 30 weeks, the flaxseed-treated mice had significantly less aggressive tumors than did the controls (P = 0.01). The prevalence of lung and lymph node metastases was 13% and 16%, respectively, in the control mice versus 5% and 12%, respectively, in the experimental group (difference not significant). After 20 weeks of treatment, cellular proliferation (Ki-67) differed significantly between the control and experimental groups (38.1 +/- 2.03 versus 26.2 +/- 2.03; P <0.0001), and the apoptotic index (deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling) was 1.45 +/- 0.14 versus 3.3 +/- 0.31 (P <0.0001). Similar differences were seen after 30 weeks of treatment. CONCLUSIONS: A diet supplemented with 5% flaxseed inhibits the growth and development of prostate cancer in the TRAMP model.


http://www.ncbi.nlm.nih.gov/entrez/q..._uids=12429338

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Old 05-13-2005, 02:21 AM   #2
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Hmm..very good news for us men that take flax oil.
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Old 05-13-2005, 03:03 AM   #3
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I love flax seed bread, but I wonder how much oil you get from 2 slices.
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Old 05-13-2005, 03:06 AM   #4
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Originally Posted by johnsbod
I love flax seed bread, but I wonder how much oil you get from 2 slices.
Hmm..I wouldn't think that much. But some is better then none.
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Old 05-13-2005, 03:09 AM   #5
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Originally Posted by DarkFalcon
Hmm..I wouldn't think that much. But some is better then none.
I have some flax seed oil gel caps, and I take those once in a while and skip the fish oil.
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Old 05-13-2005, 03:15 AM   #6
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Some good flax info...
FABULOUS FLAX: THE RICH NUTRIENTS IN FLAX
Flax oil and flax seeds are being rediscovered as true health foods. They definitely merit being included on any top-ten list of foods that are good for you. Flax is not a new food. It is actually one of the older and, perhaps, one of the original "health foods," treasured because of its healing properties throughout the Roman empire. Flax was one of the original "medicines" used by Hippocrates. Flax could be dubbed the "forgotten oil." It has fallen out of favor because oil manufacturers have found nutritious oils to be less profitable. The very nutrients that give flax its nutritional benefits - essential fatty acids - also give it a short shelf life, making it more expensive to produce, transport, and store. Yet, those who are nutritionally in the know continue to rank flax high on the list of "must have" foods. Because of the flurry of scientific studies validating the health benefits of omega 3 fatty acids, flax oil has graduated from the refrigerator of "health food nuts" to a status of scientific respectability.

I seldom leave home in the morning without having my daily tablespoon of flax oil or 2 tablespoons of flaxseed meal. Besides being the best source of omega 3's, flax oil is a good source of omega 6, or linoleic acid (LA). Sunflower, safflower, and sesame oil are greater sources of omega 6 fatty acids but they don't contain any omega-3 fatty acids. Flax oil is 45 to 60 percent the omega-3 fatty acid alphalinolenic acid (ALA).

In addition to nutritious fats, flax seeds contain other nutrients which make eating the whole seed superior to consuming just the extracted oil:

Flax seeds contain a high quality protein.

Flax seeds are rich in soluble fiber. The combination of the oil and the fiber makes flaxseeds an ideal laxative.

Flax seeds contain vitamins B-1, B-2, C, E, and carotene. These seeds also contain iron, zinc, and trace amounts of potassium, magnesium, phosphorus, calcium, and vitamin E and carotene, two nutrients which aid the metabolism of the oil.

Flax seeds contain over a hundred times more of a phytonutrient, known as lignin, than any of its closest competitors, such as wheat bran, buckwheat, rye, millet, oats, and soybeans. Lignins have received a lot of attention lately because of possible anti-cancer properties, especially in relation to breast and colon cancer. Lignins seem to flush excess estrogen out of the body, thereby reducing the incidence of estrogen-linked cancers, such as breast cancer. Besides anti-tumor properties, lignins also seem to have antibacterial, antifungal, and antiviral properties.
Flax seeds, because they contain some protein, fiber, vitamins and minerals, and lignins, are more nutritious than their oil. Yet, for practical purposes, most consumers prefer simply using the oil for its omega-3 fatty acids and not having to bother with grinding the seeds. But nutritionally speaking, it's worth the trouble to grind fresh flax seeds (say, in a coffee grinder) and sprinkle them as a seasoning on salads or cereals, or mix them into muffins. When buying seeds, be sure they are whole, not split; splitting exposes the inner seed to light and heat and decreases the nutritional value. Or, buy pre-ground flax seeds, available as flaxseed meal. One ounce of flaxseed meal (approximately 4 tbsp.) will yield about 6 grams of protein, and 8 grams of fiber.

7 HEALTH-PROMOTING PROPERTIES OF FLAX
Flax oil, flax seeds, and the omega-3 fatty acids they contain are good for your health. Here are some of the ways flax helps your body.

1. Flax promotes cardiovascular health. The ultra-high levels of omega-3 fatty acids lower LDL (bad) cholesterol levels. Fish oils and algae are also good sources of essential fatty acids.

2. Flax promotes colon health. It has anti-cancer properties and, as a natural lubricant and a rich fiber source, it lowers the risk of constipation.

3. Flax supplements can boost immunity. One study showed that school children supplemented with less than a teaspoon of flax oil a day had fewer and less severe respiratory infections than children not supplemented with flax oil.

4. Flax provides fats that are precursors for brain building. This is especially important at the stage of life when a child's brain grows the fastest, in utero and during infancy. A prudent mom should consider supplementing her diet with a daily tablespoon of flax oil during her pregnancy and while breastfeeding.

5. Flax promotes healthy skin. I have used flax oil as a dietary supplement in my patients who seem to have dry skin or eczema, or whose skin is particularly sun-sensitive.

6. Flax may lessen the severity of diabetes by stabilizing blood-sugar levels.

7. Flax fat can be slimming. Fats high in essential fatty acids, such as flax, increase the body's metabolic rate, helping to burn the excess, unhealthy fats in the body. Eating the right kind of fat gives you a better fighting chance of your body storing the right amount of fats. This is called thermogenesis , a process in which specialized fat cells throughout the body (called brown fat) click into high gear and burn more fat when activated by essential fatty acids, especially gamma-linolenic acid (GLA). I have personally noticed that I crave less fat overall when I get enough of the healthy fats. A daily supplement of omega 3 fatty acids may be an important part of weight control programs.

USING FLAX OIL
Don't use flax oil for cooking. Oils high in essential fatty acids are not good for cooking. In fact, heat can turn these healthy fats into harmful ones. Add flax oil to foods after cooking and just before serving.

Flax has many virtues, but it also has one vice: it turns rancid quickly. Healthy fats spoil quickly, with olive oil being an exception to the rule. (The fats with a long shelf life are the hydrogenated shortenings, which of course are bad for you.) To prevent spoilage, follow these tips:

Purchase only refrigerated flax oil stored in black containers.

Keep your flax oil in the refrigerator with the lid on tight. Minimize exposure to heat, light, and air.

Because the oil is likely to turn rancid within six weeks of pressing, buy flax oil in smaller containers (8-12 ounces, depending on how fast you use it). In our family, we go through approximately four tablespoons of flax oil a day, using it mainly in our School-Ade smoothie.

Flax oil taken with a meal can actually increase the nutritional value of other foods . Research shows that adding flax oil to foods rich in sulfated amino acids, such as cultured dairy products (i.e., yogurt), vegetables of the cabbage family, and animal, seafood, and soy proteins helps the essential fatty acids become incorporated into cell membranes. Mixing flax oil with yogurt helps to emulsify the oil, improving its digestion and metabolism by the body.

Flax oil works best in the body when it's taken along with antioxidants, such as vitamins E, carotene, and other nutrients, such as vitamin B6 and magnesium. While a tablespoon of flax oil a day might not keep the doctor away entirely, it's bound to help.
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Old 05-23-2005, 08:37 PM   #7
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nice, thanks for lookin out

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Old 09-24-2005, 04:09 PM   #8
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I'm sorry to bump this, especially being a total newb and all, but I am quite honestly going in circles on this flax vs. fish oil issue!

I read posts by people straight up dissing flax, saying it can actually cause you health problems along with it being not as readily available to the body as the fish oil.

However, almost all these reviews and write-ups on the flax seem to have NOTHING but praises!

Basically, from all I've read, I thought I wanted to take flax seed oil. Then I read that flax is inferior to the fish oil, go with fish oil instead. Then I read that it's better to use both, and some people still stand by the flax!

I'm poor and would just like to go with one if I could(which I assume would be the fish oil), but I like how all the health benefits of the flax sound and don't want to be missing out on a potentially very affordable and effective supplement.

A few weeks ago my grandfather gave me a few flax seed oil pills, and I swear I had forgot I took them until I realized that my joints felt a lot more coushined. Does fish oil help with joints as well?
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Old 09-26-2005, 01:24 AM   #9
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Quote:
Originally Posted by johnsbod
I love flax seed bread, but I wonder how much oil you get from 2 slices.
Not enough. Drink the shit like the rest of us :rmad:
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Old 09-26-2005, 03:41 AM   #10
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Quote:
Originally Posted by Zesty
I'm sorry to bump this, especially being a total newb and all, but I am quite honestly going in circles on this flax vs. fish oil issue!

I read posts by people straight up dissing flax, saying it can actually cause you health problems along with it being not as readily available to the body as the fish oil.
I've seen people post on both sides of the issue as well. And there have been posts by members whose advice I respect saying fish oil is better than flax oil.

But for right now I'm still using both flax and fish oil myself until I see more evidence to change.
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Old 09-26-2005, 04:55 PM   #11
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^Thanks for the reply.

As I understand it, the flax is actually higher in Omega 3's, but the fish oil's omega 3's are more available to the human body.

Question: I have read quite a few articles explaining the benefits of flax seed oil, which it seems are numerous. Is this a result of being high in omega 3's, or just the nature of the oil itself?

basically, will fish oil give me all the benefits of flax oil, or does the flax have benefits that the fish oil doesn't?

I guess I'm just wondering if it's overkill to take both, and if the health benefits are the same.

Sorry for the dumb questions! I'll get better, I promise. LOL
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