ALRI's Lipolytic whey.... OEA 'magic ingredient' debate

**skelooth** · 06-17-2006, 10:13 PM

Does any one have any experience with OEA by it's self? I've never heard of it before myself and will prolly look into it some more later, but:

the full write up says that OEA caused rats to oxidize fat via PPAR activation....

is this not the SAME EXACT results of CLA research??? :scared:

**skelooth** · 06-17-2006, 11:01 PM

here is a PDF file documenting one of the rat studies. I'm still looking around for research on humans or results in humans.

Notabley, Red Acid by Controlled Labs also contains OEA (or it's proper name oleoylethanolamide)

http://www.cmcr.ucsd.edu/geninfo/11_Fu.pdf

**skelooth** · 06-17-2006, 11:06 PM

It is generally believed that this kind of lipid amide is rapidly catabolized in the gastrointestinal tract, thereby preventing its use as an oral anti-obesity compound," scientists in Denmark report.
from http://www.newsrx.com/newsletters/Ob...0433347OD.html

I'm getting closer to the answers I seek...

OEA is a pretty damn long chain. I would NOT want to have to work with it in chem class

**skelooth** · 06-17-2006, 11:23 PM

http://ajpregu.physiology.org/cgi/co...ct/290/5/R1407

^^ Very intersting.. but

Bingo I think http://thediabeticnews.com/news/901.shtml

seems like the best info I'm going to find on the topic w/o paying for access to someone's research. I'm really getting the impression that OEA is much more of an appetite suppressant than it is a ppar activator.... I'm also getting the impression that it would be best taken in a fasted state.... but during a higher fat diet.

Very strange indeed. I'm not quite sure what my stance on OEA is yet. It's certainly not new... as I've found a few other well known but much older thermogenics that contain it as an ingredient. The first reports of OEA started surfacing around 2002 out of california.

I always feel more than just a little bit critical about studies done on rats. Humans are not rats... and there are so many studies that 'work' in animals and not humans. When will the medical research industry realize this? "OMG IT WORKS IN RATS IT MUST WORK IN HUMANS!!!!" The worst part is that things that don't work on rats might work on humans, so they will never make it to market.

**powerman2000** · 06-18-2006, 08:34 AM

Quote:

Originally Posted by skelooth

I always feel more than just a little bit critical about studies done on rats. Humans are not rats... and there are so many studies that 'work' in animals and not humans. When will the medical research industry realize this? "OMG IT WORKS IN RATS IT MUST WORK IN HUMANS!!!!" The worst part is that things that don't work on rats might work on humans, so they will never make it to market.

^^^ Agreed!

Hybrid · 06-19-2006, 02:02 AM

Very interesting Skel! Musta done some hard digging, it's obvious. Good stuff!!

**Blap Blaow** · 06-19-2006, 02:18 AM

I vaguely recall OEA being a part of the 'big debate/flamefest' on Red Acid over on bb.com when RA first came out. May be worth digging up if you're interested.

**skelooth** · 06-19-2006, 02:25 AM

Interesting Blap! Out of curiousity what was the debate/flamefest over? Is it what I just dug up? IE the fact that it gets catabolized in the digestive track? That's actually pretty big, because if it's true that means OEA is useless unless MEGA DOSED at insane amounts or it's engineered or taken in some alternate way. The other issue is the exact mechanisms it oxidizes fat by, and if it has the same result in humans as it does in rats.

**Blap Blaow** · 06-19-2006, 02:50 AM

Yes, that was part of it. It was a lot of things; mainly personal/professional grudges, scientific disagreement and the fact that many didn't like that fact that contains Red Acid a large propietary blend.

HERE is a link to the infamous Red Acid FAQ.

HERE is a thread on OEA science which turned up as a result.

Phosphate bond · 06-19-2006, 04:39 AM

Scivation used a more bioavailable form of this stuff in their lipid Fx (basically it is the phospholipid form of OEA if I remember correctly)

**jkeithc82** · 07-06-2006, 02:59 PM

Quote:

Originally Posted by Phosphate bond

Scivation used a more bioavailable form of this stuff in their lipid Fx (basically it is the phospholipid form of OEA if I remember correctly)

I believe this is correct.

06-17-2006, 10:13 PM	#1
skelooth eh heh heh Join Date: Aug 2005 Location: Behind you Posts: 7,205 Recipes: 0 Rep Power: 158	ALRI's Lipolytic whey.... OEA 'magic ingredient' debate Does any one have any experience with OEA by it's self? I've never heard of it before myself and will prolly look into it some more later, but: the full write up says that OEA caused rats to oxidize fat via PPAR activation.... is this not the SAME EXACT results of CLA research??? :scared: __________________ R I P

06-17-2006, 11:01 PM	#2
skelooth eh heh heh Join Date: Aug 2005 Location: Behind you Posts: 7,205 Recipes: 0 Rep Power: 158	here is a PDF file documenting one of the rat studies. I'm still looking around for research on humans or results in humans. Notabley, Red Acid by Controlled Labs also contains OEA (or it's proper name oleoylethanolamide) http://www.cmcr.ucsd.edu/geninfo/11_Fu.pdf __________________ R I P

06-17-2006, 11:06 PM	#3
skelooth eh heh heh Join Date: Aug 2005 Location: Behind you Posts: 7,205 Recipes: 0 Rep Power: 158	It is generally believed that this kind of lipid amide is rapidly catabolized in the gastrointestinal tract, thereby preventing its use as an oral anti-obesity compound," scientists in Denmark report. from http://www.newsrx.com/newsletters/Ob...0433347OD.html I'm getting closer to the answers I seek... OEA is a pretty damn long chain. I would NOT want to have to work with it in chem class __________________ R I P

06-17-2006, 11:23 PM	#4
skelooth eh heh heh Join Date: Aug 2005 Location: Behind you Posts: 7,205 Recipes: 0 Rep Power: 158	http://ajpregu.physiology.org/cgi/co...ct/290/5/R1407 ^^ Very intersting.. but Bingo I think http://thediabeticnews.com/news/901.shtml seems like the best info I'm going to find on the topic w/o paying for access to someone's research. I'm really getting the impression that OEA is much more of an appetite suppressant than it is a ppar activator.... I'm also getting the impression that it would be best taken in a fasted state.... but during a higher fat diet. Very strange indeed. I'm not quite sure what my stance on OEA is yet. It's certainly not new... as I've found a few other well known but much older thermogenics that contain it as an ingredient. The first reports of OEA started surfacing around 2002 out of california. I always feel more than just a little bit critical about studies done on rats. Humans are not rats... and there are so many studies that 'work' in animals and not humans. When will the medical research industry realize this? "OMG IT WORKS IN RATS IT MUST WORK IN HUMANS!!!!" The worst part is that things that don't work on rats might work on humans, so they will never make it to market. __________________ R I P

06-19-2006, 02:02 AM	#6
Hybrid IMPC Contestant Join Date: Oct 2005 Location: Gibsonia PA Posts: 824 Recipes: 0 Rep Power: 14	Very interesting Skel! Musta done some hard digging, it's obvious. Good stuff!! __________________ If you even dream about beating me you'd better wake up and apologize - Muhammad Ali

06-19-2006, 02:18 AM	#7
Blap Blaow IronMass Sponsor Join Date: Oct 2005 Location: London, England Posts: 950 Recipes: 0 Rep Power: 32	I vaguely recall OEA being a part of the 'big debate/flamefest' on Red Acid over on bb.com when RA first came out. May be worth digging up if you're interested. __________________ Blapmungous™

06-19-2006, 02:25 AM	#8
skelooth eh heh heh Join Date: Aug 2005 Location: Behind you Posts: 7,205 Recipes: 0 Rep Power: 158	Interesting Blap! Out of curiousity what was the debate/flamefest over? Is it what I just dug up? IE the fact that it gets catabolized in the digestive track? That's actually pretty big, because if it's true that means OEA is useless unless MEGA DOSED at insane amounts or it's engineered or taken in some alternate way. The other issue is the exact mechanisms it oxidizes fat by, and if it has the same result in humans as it does in rats. __________________ R I P

06-19-2006, 02:50 AM	#9
Blap Blaow IronMass Sponsor Join Date: Oct 2005 Location: London, England Posts: 950 Recipes: 0 Rep Power: 32	Yes, that was part of it. It was a lot of things; mainly personal/professional grudges, scientific disagreement and the fact that many didn't like that fact that contains Red Acid a large propietary blend. HERE is a link to the infamous Red Acid FAQ. HERE is a thread on OEA science which turned up as a result. __________________ Blapmungous™

06-19-2006, 04:39 AM	#10
Phosphate bond Amateur Join Date: Aug 2005 Posts: 77 Recipes: 0 Rep Power: 4	Scivation used a more bioavailable form of this stuff in their lipid Fx (basically it is the phospholipid form of OEA if I remember correctly) __________________ www.MolecularNutrition.net www.BodyofScience.com

Thread Tools
Show Printable Version Email this Page
Display Modes
Linear Mode Switch to Hybrid Mode Switch to Threaded Mode