The after taste of syntrax guggulbolic....

**skelooth** · 09-04-2005, 04:22 PM

is DISGUSTING :sick: And I thought fish and flax oil were bad.... damn.

What do you guys think of the latest research that gugglesterones are a bunk scam from india? I'm taking them anyway....

**EME** · 09-04-2005, 04:27 PM

Hmmm...

Hey Skeelo, are you opening caps and pouring the guggul in like Pop rocks???

How are you tasting it?

I wash my caps down with a little E-C-A and a diet coke, and it's all good. :eat:

As for the effectiveness of Guggul supps, I have found that they are significantly more effective when stacked with ECA, than when taken alone. I've read some science to back that up too,... I'll see if I can find a link, or the text... I usually save that stuff.

- EME

**skelooth** · 09-04-2005, 04:35 PM

Everything is more effective with ECA (Even cookie dough

)

I'll have to pull up a link/quote about guggles for you too, it makes me think twice...

Here we go:

Quote:

First the study that it raises cholesterol and now this study.

Why are people still putting this in supplements?

Mol Pharmacol. 2005 Mar;67(3):948-54. Epub 2004 Dec 15. Related Articles, Links

The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand.

Burris TP, Montrose C, Houck KA, Osborne HE, Bocchinfuso WP, Yaden BC, Cheng CC, Zink RW, Barr RJ, Hepler CD, Krishnan V, Bullock HA, Burris LL, Galvin RJ, Bramlett K, Stayrook KR.

Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA. burris@lilly.com

Guggulsterone (GS) is the active substance in guggulipid, an extract of the guggul tree, Commiphora mukul, used to treat a variety of disorders in humans, including dyslipidemia, obesity, and inflammation. The activity of GS has been suggested to be mediated by antagonism of the receptor for bile acids, the farnesoid X receptor (FXR). Here, we demonstrate that both stereoisomers of the plant sterol, (E)- and (Z)-GS, bind to the steroid receptors at a much higher affinity than to FXR. Both stereoisomers bind to the mineralocorticoid receptor (MR) with a Ki value of approximately 35 nM, which is greater than 100 times more potent than their affinity for FXR. Both (E)- and (Z)-GS also displayed high affinity for other steroid receptors, including the androgen (AR), glucocorticoid (GR), and progesterone receptors (PR) with Ki values ranging from 224 to 315 nM. In cell-based functional cotransfection assays, GSs behaved as antagonists of AR, GR, and MR, but as agonists of PR. Agonist activity was also demonstrated with estrogen receptor (ER) alpha; however, the potency was very low (EC50 > 5000 nM). In addition, GS displayed activity in functional assays in cell lines expressing endogenous AR, GR, ER, and PR. These data suggest that the variety of pharmacological effects exhibited by GS may be mediated by targeting several steroid receptors.

http://forum.bodybuilding.com/showthread.php?t=466547

09-04-2005, 04:22 PM	#1
skelooth eh heh heh Join Date: Aug 2005 Location: Behind you Posts: 7,205 Recipes: 0 Rep Power: 158	The after taste of syntrax guggulbolic.... is DISGUSTING :sick: And I thought fish and flax oil were bad.... damn. What do you guys think of the latest research that gugglesterones are a bunk scam from india? I'm taking them anyway.... __________________ R I P

09-04-2005, 04:27 PM	#2
EME Super Moderator Join Date: Mar 2005 Posts: 3,265 Recipes: 0 Rep Power: 51	Hmmm... Hey Skeelo, are you opening caps and pouring the guggul in like Pop rocks??? How are you tasting it? I wash my caps down with a little E-C-A and a diet coke, and it's all good. :eat: As for the effectiveness of Guggul supps, I have found that they are significantly more effective when stacked with ECA, than when taken alone. I've read some science to back that up too,... I'll see if I can find a link, or the text... I usually save that stuff. - EME __________________ PhysiqueFXonline - Online Nutrition and Training with Michael and Kendra Elias: www.MichaelandKendra.com Team Molecular Nutrition Creative Director FAME Media Group / World Natural Sports Organization Editor-In-Chief FAME Magazine www.FAMEWorldTour.com

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