New hormone that may significantly extend life-- interesting read

Aftershock · 08-27-2005, 08:21 PM

WASHINGTON - Scientists have identified a hormone that significantly extends the life span of mice, a discovery that could mark a crucial step toward developing drugs that boost longevity in people.

The hormone is the first substance identified that is produced naturally in mammals, including humans, and can extend life span - a long-sought goal in the intense effort to help people live longer.

Much more work is needed to study the substance and investigate whether the hormone or a similar compound would be effective and safe in people, experts cautioned. But the discovery opens highly promising avenues for research and provides tantalizing new clues toward deciphering the basic biology of aging.

"This is a significant discovery. It's an exciting paper," said Anna McCormick of the National Institute on Aging, which helped fund the new research, published online Thursday by the journal Science. "It's definitely the way you would go about designing molecules that would promote healthy aging and longevity in people."

Makoto Kuro-o of the University of Texas Southwestern Medical Center at Dallas, who led the research, said, "This could provide a key to understanding the molecular mechanisms of aging and opens up new areas to the potential therapy for multiple age-related diseases in humans."

The discovery was triggered by a study Kuro-o and his colleagues published in 1997 that identified a gene in mice that, when damaged, caused the animals to experience all the hallmarks of aging in humans - hardening of the arteries, thinning bones, withered skin, weak lungs - and to die prematurely. They dubbed the gene Klotho, for the Greek goddess who spins the thread of life.

Suspecting the gene may play a role in regulating life span, Kuro-o and his colleagues genetically engineered mice with overactive Klotho genes. In the latest experiments, they found that these animals lived an average of 20 percent to 30 percent longer than normal - 2.4 to 2.6 years versus a normal life span of about two years - without any signs of ill effects, according to the new report.

"The extension of life span is widely accepted as a reliable marker for the suppression of aging," Kuro-o said. "This shows the Klotho gene regulates aging."

http://www.newsday.com/news/health/n...,4451711.story

**Peaked_18** · 08-27-2005, 08:39 PM

Interesting.

Personally humans are creatine life and I think they might be going to far. Remember CLA made mice lose weight, but not well for humans.

I want to see some tests on humans.

Thanks AS

Vegeto · 08-27-2005, 08:58 PM

I wonder which glands produce the hormone?

Aftershock · 08-29-2005, 07:14 AM

Peaked- good point.

Vegeto- Yeah, I'm kind of curious too.

Diab0lic · 08-29-2005, 10:41 AM

http://www.ncbi.nlm.nih.gov/entrez/q...266&query_hl=1

Heres the study, its new and hasnt gone to print yet so there aint much available

**Pioneer** · 08-29-2005, 05:52 PM

i can see this doing more bad then good.

DarkFalcon · 08-29-2005, 09:46 PM

Interesting, but I think if you want people to live longer cures for things like cancer would be a better start.

**powerman2000** · 08-30-2005, 02:56 AM

Quote:

Originally Posted by DarkFalcon

Interesting, but I think if you want people to live longer cures for things like cancer would be a better start.

Amen to that!

Diab0lic · 08-31-2005, 10:47 AM

Quote:

Originally Posted by DarkFalcon

Interesting, but I think if you want people to live longer cures for things like cancer would be a better start.

Cancer is teh suxor :sick:

Apootheosis · 08-31-2005, 10:15 PM

we need something that will enhance human life, at the same time decreasing it's length.

Needing several artificial joints, suffering from chronic lung and joint pain, uncontrallable bowel movements, atrophied muscle, memory loss, impaired hearing, vision, and brain function is just too inefficient for me to consider an acceptable life.

Brinn · 09-09-2005, 06:13 AM

Quote:

Originally Posted by Vegeto

I wonder which glands produce the hormone?

http://www.innovitaresearch.org/news/03082101.html

Quote:

Expression of KLOTHO mRNA occurs primarily in the placenta, kidney, prostate, and small intestine.

KingOfChaos · 09-27-2005, 06:13 PM

Quote:

Scientists have identified a hormone that significantly extends the life span of mice, a discovery that could mark a crucial step toward developing drugs that boost longevity in people.

Perhaps I have high levels of this hormone and that's why I look like I am 15 years old even though I am nearly 26. :P

Vegeto · 09-27-2005, 06:16 PM

Quote:

Originally Posted by Brinn

http://www.innovitaresearch.org/news/03082101.html

For some reason, I couldn't pick up whether Klotho Mrna was what caused aging, and suppressing it was what slows aging, or if Klotho Mrna itself is what slowed down the aging process... I have to read that again.

**skelooth** · 10-30-2005, 06:14 PM

If people start living longer than they already do, our economy is going to go down the crapper. Old people don't work, they just sit around and collect money, then they bargain hunt.

Our economy would be healthier if we started offing some of the baby boomers :rmad:

**Ikaika** · 10-31-2005, 09:09 PM

Quote:

Originally Posted by skelooth

If people start living longer than they already do, our economy is going to go down the crapper. Old people don't work, they just sit around and collect money, then they bargain hunt.

Our economy would be healthier if we started offing some of the baby boomers :rmad:

I don't quite see how an increase in the number of elderly people will send our economy to the crapper, seeing as social security and medicaid are already FUBAR.

KingOfChaos · 12-13-2005, 10:10 PM

Great...lets extend the life of people who most likely don't deserve it. Do you really think the common people will get this or the powerful and rich?

**bubba g** · 12-13-2005, 10:36 PM

08-27-2005, 08:21 PM	#1
Aftershock Steel Pimp Join Date: Apr 2005 Posts: 285 Recipes: 0 Rep Power: 6	New hormone that may significantly extend life-- interesting read WASHINGTON - Scientists have identified a hormone that significantly extends the life span of mice, a discovery that could mark a crucial step toward developing drugs that boost longevity in people. The hormone is the first substance identified that is produced naturally in mammals, including humans, and can extend life span - a long-sought goal in the intense effort to help people live longer. Much more work is needed to study the substance and investigate whether the hormone or a similar compound would be effective and safe in people, experts cautioned. But the discovery opens highly promising avenues for research and provides tantalizing new clues toward deciphering the basic biology of aging. "This is a significant discovery. It's an exciting paper," said Anna McCormick of the National Institute on Aging, which helped fund the new research, published online Thursday by the journal Science. "It's definitely the way you would go about designing molecules that would promote healthy aging and longevity in people." Makoto Kuro-o of the University of Texas Southwestern Medical Center at Dallas, who led the research, said, "This could provide a key to understanding the molecular mechanisms of aging and opens up new areas to the potential therapy for multiple age-related diseases in humans." The discovery was triggered by a study Kuro-o and his colleagues published in 1997 that identified a gene in mice that, when damaged, caused the animals to experience all the hallmarks of aging in humans - hardening of the arteries, thinning bones, withered skin, weak lungs - and to die prematurely. They dubbed the gene Klotho, for the Greek goddess who spins the thread of life. Suspecting the gene may play a role in regulating life span, Kuro-o and his colleagues genetically engineered mice with overactive Klotho genes. In the latest experiments, they found that these animals lived an average of 20 percent to 30 percent longer than normal - 2.4 to 2.6 years versus a normal life span of about two years - without any signs of ill effects, according to the new report. "The extension of life span is widely accepted as a reliable marker for the suppression of aging," Kuro-o said. "This shows the Klotho gene regulates aging." http://www.newsday.com/news/health/n...,4451711.story __________________ sholiz: im drunk and i want some fruit loops Aftershock: no i know you need to maintain a certain level of professionalism on ironmass Aftershock: how easily i can destroy that... sholiz: just in appearance `````````\\|\|\|/ `````````(o o) ,--ooO-----(_)-------------, \|````````` Aftershock ````\| \|```````````is```````````\| \|``````````sexy````````` \| '--------------Ooo----------' ````````\|__\|__\| `````````\|\|\| \|\| ````````ooO Ooo

08-27-2005, 08:58 PM	#3
Vegeto blameless sinner Join Date: May 2005 Location: Minnesota Posts: 803 Recipes: 0 Rep Power: 15	I wonder which glands produce the hormone? __________________ ______________ ________________ ......Busy Training...... __________________ ________________ __________________

08-29-2005, 07:14 AM	#4
Aftershock Steel Pimp Join Date: Apr 2005 Posts: 285 Recipes: 0 Rep Power: 6	Peaked- good point. Vegeto- Yeah, I'm kind of curious too. __________________ sholiz: im drunk and i want some fruit loops Aftershock: no i know you need to maintain a certain level of professionalism on ironmass Aftershock: how easily i can destroy that... sholiz: just in appearance `````````\\|\|\|/ `````````(o o) ,--ooO-----(_)-------------, \|````````` Aftershock ````\| \|```````````is```````````\| \|``````````sexy````````` \| '--------------Ooo----------' ````````\|__\|__\| `````````\|\|\| \|\| ````````ooO Ooo

08-29-2005, 10:41 AM	#5
Diab0lic Pro Stature Join Date: May 2005 Location: NZ Posts: 125 Recipes: 0 Rep Power: 7	http://www.ncbi.nlm.nih.gov/entrez/q...266&query_hl=1 Heres the study, its new and hasnt gone to print yet so there aint much available __________________

08-29-2005, 05:52 PM	#6
Pioneer Moderator Join Date: Jun 2005 Posts: 1,726 Recipes: 0 Rep Power: 75	i can see this doing more bad then good. __________________ "A Marine in battle fears disgracing himself by running. He fears not losing his life, but losing his honor. He may not be able to preserve his life, but he can always preserve his honor. That much is within his power... To fear disgrace but not death, to fear not duty but dereliction from duty -- this is courage." -FMFM 1-0 "Leading Marines" pg. 43 Drive on

08-27-2005, 08:39 PM	#2
Peaked_18 a la commode Join Date: May 2005 Posts: 4,247 Recipes: 2 Rep Power: 96	Interesting. Personally humans are creatine life and I think they might be going to far. Remember CLA made mice lose weight, but not well for humans. I want to see some tests on humans. Thanks AS

08-29-2005, 09:46 PM	#7
DarkFalcon I've got a RAGING clue! Join Date: May 2005 Location: dnyc99's cleaning staff Posts: 11,511 Recipes: 0 Rep Power: 299	Interesting, but I think if you want people to live longer cures for things like cancer would be a better start.

08-31-2005, 10:15 PM	#10
Apootheosis Pro Stature Join Date: May 2005 Posts: 625 Recipes: 0 Rep Power: 10	we need something that will enhance human life, at the same time decreasing it's length. Needing several artificial joints, suffering from chronic lung and joint pain, uncontrallable bowel movements, atrophied muscle, memory loss, impaired hearing, vision, and brain function is just too inefficient for me to consider an acceptable life. __________________ lawlz

10-30-2005, 06:14 PM	#14
skelooth eh heh heh Join Date: Aug 2005 Location: Behind you Posts: 7,205 Recipes: 0 Rep Power: 158	If people start living longer than they already do, our economy is going to go down the crapper. Old people don't work, they just sit around and collect money, then they bargain hunt. Our economy would be healthier if we started offing some of the baby boomers :rmad: __________________ R I P

12-13-2005, 10:10 PM	#16
KingOfChaos Pro Stature Join Date: Sep 2005 Location: Temple, TX Posts: 156 Recipes: 0 Rep Power: 7	Great...lets extend the life of people who most likely don't deserve it. Do you really think the common people will get this or the powerful and rich? __________________ Shawn Muder Bodybuilding Enthusiast Fire Controlman, United States Navy Starting Weight: 520 lbs. BF - 62% (3/24/04) Current Weight: 315 lbs. BF - 22% (03/09/08) MySpace: http://www.myspace.com/darkspeaker Livejournal: http://www.livejournal.com/~kingoflaw/ Realms of Evil, My D&D website: http://www.realmsofevil.net/

12-13-2005, 10:36 PM	#17
bubba g Moderator Join Date: Sep 2005 Posts: 2,949 Recipes: 0 Rep Power: 177	Quo